Moderna vs Pfizer: Is it OK to mix and match the updated COVID-19 booster shots?

Vials of Pfizer's bivalent COVID-19 vaccine.
Vials of Pfizer’s bivalent COVID-19 vaccine at a producing facility in Kalamazoo, Mich.
(Pfizer through Related Press)

As residents put together to roll up their sleeves for a 3rd, fourth or even fifth dose of COVID-19 vaccine, some could also be questioning: Do I would like to stay with the identical model, or is it secure to combine it up?

Relating to the new COVID-19 Omicron bivalent booster, the reply is, sure, you possibly can combine and match.

You will get both the Pfizer-BioNTech or Moderna model, no matter which providing you beforehand acquired.

“The perfect booster for you is the one which you could get — both the Pfizer or the Moderna can be utilized, and they are often blended or matched,” stated Dr. Robert Kim-Farley, epidemiologist and infectious illness professional on the UCLA Fielding College of Public Well being. “If there’s shortages of 1, you shouldn't have hesitancy to take the opposite.”

Mixing and matching

Say an individual has acquired three doses of the Moderna shot. Ought to they stick with Moderna or combine it up with a Pfizer booster?

The impact on the physique’s immune system ought to be comparable both approach, UC San Francisco infectious illness professional Dr. Peter Chin-Hong wrote in a tweet.

“It’s OK to combine and match Moderna and Pfizer,” Dr. Ralph Gonzales, affiliate dean for scientific innovation and chief innovation officer for UC San Francisco, stated at a campus city corridor final week. “I simply acquired my Moderna two days in the past and it was an fascinating expertise. I undoubtedly felt a stronger response with the Moderna — having had Pfizer earlier than — however both combos are wonderful.”

The U.S. Meals and Drug Administration truly allowed mixing and matching of COVID-19 booster doses beginning final yr, after it allowed folks to get their first booster dose. Regardless of having the selection, although, lots of people ended up staying model loyal.

However others switched it up, both as a matter of choice, availability or advice. A lot of those that initially acquired the single-dose Johnson & Johnson vaccine, as an example, opted for Pfizer or Moderna come booster time.

What's subsequent

When some folks — these age 50 and up and the immunocompromised — turned eligible for a second typical booster shot earlier this yr, some determined to go together with the opposite model. Dr. Robert Wachter, chair of the UC San Francisco Division of Drugs, in April determined to go together with Moderna for his fourth shot after three consecutive Pfizers.

“I noticed it as a toss-up,” he tweeted on the time.

The up to date Omicron bivalent booster shot is offered to these age 12 and up. Adults can select from both Pfizer or Moderna; adolescents age 12 to 17 are solely eligible for Pfizer.

L.A. County Public Well being Director Barbara Ferrer stated there’s some expectation that the up to date booster shall be obtainable for youngsters age 5 to 11 maybe as quickly as October.

Officers are urging folks to get the up to date booster, which they anticipate will scale back the chance of an infection. It’s referred to as a bivalent shot as a result of it’s designed to guard not solely towards the unique coronavirus pressure, but additionally the newest Omicron subvariants which have dominated the nation this summer season, together with BA.5.

“The bivalent boosters present safety towards the subvariants which are at the moment circulating on the highest ranges, they usually’re going to be one in all our greatest instruments in planning for a secure, more healthy and happier fall and winter vacation season,” Ferrer stated Thursday.

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